Brønsted Acid-Catalyzed Dipeptides Functionalization through Azlactones
نویسندگان
چکیده
منابع مشابه
Chiral Brønsted acid catalyzed stereoselective addition of azlactones to 3-vinylindoles for facile access to enantioenriched tryptophan derivatives.
Syn-gled out: The syn diastereo- and enantioselective addition of azlactones to 3-vinylindoles was accomplished by using a chiral, binapthol-derived, Brønsted acid catalyst (see scheme). This method enables facile access to tryptophan derivatives with adjacent quaternary and tertiary stereogenic centers, which are potentially useful for the synthesis of peptidomimetics.
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This paper describes an enantioselective intermolecular allylic amination catalyzed by a chiral Brønsted acid via a possible chiral contact ion pair intermediate. A variety of symmetrical or unsymmetrical allylic alcohols can be smoothly aminated to afford the desired products in moderate to high yields with good enantioselectivities and/or regioselectivities.
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2017
ISSN: 0103-5053
DOI: 10.21577/0103-5053.20170058